abstract：:Bone marrow-derived mesenchymal stem/progenitor cells (BMSCs) are commonly used in regeneration therapy. The current primary source of BMSCs is the iliac crest; however, the procedure is associated with various burdens on the patient, including the risk of pain and infection. Hence, the possibility to collect BMSCs fr...

journal_title：Journal of dental research

authors： Nakajima R,Ono M,Hara ES,Oida Y,Shinkawa S,Pham HT,Akiyama K,Sonoyama W,Maekawa K,Kuboki T

更新日期：2014-11-01 00:00:00

abstract：:During the maintenance of bone marrow-derived mesenchymal stem cells (BMMSCs), suspended cells are discarded normally. We noted the osteogenic potential of these cells to be like that of anchorage-dependent BMMSCs. Therefore, we characterized suspended BMMSCs from rabbit bone marrow by bioengineering and applied the s...

journal_title：Journal of dental research

authors： Zheng RC,Park YK,Cho JJ,Kim SK,Heo SJ,Koak JY,Lee JH

更新日期：2014-10-01 00:00:00

abstract：:Tooth enamel is the most highly mineralized tissue in vertebrates. Enamel crystal formation and elongation should be well controlled to achieve an exceptional hardness and a compact microstructure. Enamel matrix calcification occurs with several matrix proteins, such as amelogenin, enamelin, and ameloblastin. Among th...

journal_title：Journal of dental research

authors： Cho ES,Kim KJ,Lee KE,Lee EJ,Yun CY,Lee MJ,Shin TJ,Hyun HK,Kim YJ,Lee SH,Jung HS,Lee ZH,Kim JW

更新日期：2014-10-01 00:00:00

abstract：:The aim of this meta-analysis, based on individual participant data from several studies, was to investigate the influence of patient-, materials-, and tooth-related variables on the survival of posterior resin composite restorations. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA...

journal_title：Journal of dental research

authors： Opdam NJ,van de Sande FH,Bronkhorst E,Cenci MS,Bottenberg P,Pallesen U,Gaengler P,Lindberg A,Huysmans MC,van Dijken JW

更新日期：2014-10-01 00:00:00

abstract：:Periostin is a mesenchymal cell marker predominantly expressed in collagen-rich fibrous connective tissues, including heart valves, tendons, perichondrium, periosteum, and periodontal ligament (PDL). Knockdown of periostin expression in mice results in early-onset periodontitis and failure of cardiac healing after acu...

journal_title：Journal of dental research

authors： Yamada S,Tauchi T,Awata T,Maeda K,Kajikawa T,Yanagita M,Murakami S

更新日期：2014-09-01 00:00:00

abstract：:A full understanding of the key regulators controlling periodontal development and homeostasis is necessary for the design of improved periodontal regenerative therapies. Small leucine-rich proteoglycans (SLRPs) are extracellular matrix molecules suggested to regulate collagen organization and cell signaling. Mice wit...

journal_title：Journal of dental research

authors： Wang L,Foster BL,Kram V,Nociti FH Jr,Zerfas PM,Tran AB,Young MF,Somerman MJ

更新日期：2014-08-01 00:00:00

abstract：:Porcine dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in dentin. It is processed by proteases into 3 independent proteins: dentin sialoprotein (DSP), dentin glycoprotein (DGP), and dentin phosphoprotein (DPP). We fractionated DPP and DSP along with TGF-β activity by ion exchange (IE) c...

journal_title：Journal of dental research

authors： Yamakoshi Y,Kinoshita S,Izuhara L,Karakida T,Fukae M,Oida S

更新日期：2014-07-01 00:00:00

abstract：:We evaluated the predictive and construct validity of a caries activity assessment system associated with the International Caries Detection and Assessment System (ICDAS) in primary teeth. A total of 469 children were reexamined: participants of a caries survey performed 2 yr before (follow-up rate of 73.4%). At basel...

journal_title：Journal of dental research

authors： Guedes RS,Piovesan C,Ardenghi TM,Emmanuelli B,Braga MM,Ekstrand KR,Mendes FM

更新日期：2014-07-01 00:00:00

abstract：:Hereditary diseases affecting the skeleton are heterogeneous in etiology and severity. Though many of these conditions are individually rare, the total number of people affected is great. These disorders often include dental-oral-craniofacial (DOC) manifestations, but the combination of the rarity and lack of in-depth...

journal_title：Journal of dental research

authors： Foster BL,Ramnitz MS,Gafni RI,Burke AB,Boyce AM,Lee JS,Wright JT,Akintoye SO,Somerman MJ,Collins MT

更新日期：2014-07-01 00:00:00

abstract：:In this study, we analyzed the influence of prosthetic abutment height on marginal bone loss (MBL) around implants in the posterior maxilla. In this retrospective cohort study, the radiographically determined MBL was related to the height of the abutments of internal conical connection implants at 6 and 18 months post...

journal_title：Journal of dental research

authors： Galindo-Moreno P,León-Cano A,Ortega-Oller I,Monje A,Suárez F,ÓValle F,Spinato S,Catena A

更新日期：2014-07-01 00:00:00

abstract：:A double-blind randomized clinical trial was performed in 6- to 7-yr-old schoolchildren to evaluate, in a 30-mo period, whether the caries increment on the distal surface of the second primary molars adjacent to permanent first molars sealed with fluoride release compounds would be lower with respect to those adjacent...

journal_title：Journal of dental research

authors： Cagetti MG,Carta G,Cocco F,Sale S,Congiu G,Mura A,Strohmenger L,Lingström P,Campus G,Italian Experimental Group on Oral Health.

更新日期：2014-07-01 00:00:00

abstract：:One-step incomplete excavation seals caries-affected dentin under a restoration and appears to be advantageous in the treatment of deep lesions. However, it is impossible to discriminate radiographically between intentionally left, arrested lesions and overlooked or active lesions. This diagnostic uncertainty decrease...

journal_title：Journal of dental research

authors： Schwendicke F,Meyer-Lueckel H,Schulz M,Dörfer CE,Paris S

更新日期：2014-06-01 00:00:00

abstract：:TWIST1 plays a crucial role in dentinogenesis, and its activity depends on both a dimerization partner selection and phosphorylation. Other factors, like Id proteins, can affect the availability of dimerization partners for TWIST1, subsequently leading to diverse biological outcomes. The purpose of this study was to e...

journal_title：Journal of dental research

authors： Maciejewska I,Sakowicz-Burkiewicz M,Pawelczyk T

更新日期：2014-06-01 00:00:00

abstract：:Teeth develop through distinct morphological stages. At the cap stage, a compactly clustered and concentrically arranged cell mass, the enamel knot, appears at the tip of the enamel organ. Cells in this knot express sets of key molecules, and as such have been proposed to act as a signaling center directing tooth morp...

journal_title：Journal of dental research

authors： Liu M,Zhao S,Wang XP

更新日期：2014-05-01 00:00:00

abstract：:Autoimmune responses to heat-shock protein 60 (HSP60) contribute to the progression of atherosclerosis, whereas immunization with HSP60 may induce atheroprotective responses. We assessed the capacity of an atheroprotective vaccine that targeted a recombinant HSP60 from Porphyromonas gingivalis (rGroEL) to induce a pro...

journal_title：Journal of dental research

authors： Hagiwara M,Kurita-Ochiai T,Kobayashi R,Hashizume-Takizawa T,Yamazaki K,Yamamoto M

更新日期：2014-04-01 00:00:00

abstract：:Although proanthocyanidins (PACs) modify dentin, the effectiveness of different PAC sources and the correlation with their specific chemical composition are still unknown. This study describes the chemical profiling of natural PAC-rich extracts from 7 plants using ultra high pressure/performance liquid chromatography ...

journal_title：Journal of dental research

authors： Aguiar TR,Vidal CM,Phansalkar RS,Todorova I,Napolitano JG,McAlpine JB,Chen SN,Pauli GF,Bedran-Russo AK

更新日期：2014-04-01 00:00:00

abstract：:PAX9 is a transcription factor expressed in the tooth mesenchyme during tooth morphogenesis. In Pax9-null mice, tooth development is arrested at the bud stage. In humans, heterozygous mutations in PAX9 have been associated with non-syndromic tooth agenesis, predominantly in the molars. Here, we report 2 novel mutation...

journal_title：Journal of dental research

authors： Mitsui SN,Yasue A,Masuda K,Watanabe K,Horiuchi S,Imoto I,Tanaka E

更新日期：2014-03-01 00:00:00

abstract：:Degradation of dentin matrix components within caries dentin has been correlated with the activity of host-derived proteases, such as matrix metalloproteases (MMPs) and cysteine cathepsins (CTs). Since this relationship has not been fully established, we hypothesized that the abundance of MMPs and CTs in caries-affect...

journal_title：Journal of dental research

authors： Vidal CM,Tjäderhane L,Scaffa PM,Tersariol IL,Pashley D,Nader HB,Nascimento FD,Carrilho MR

更新日期：2014-03-01 00:00:00

abstract：:Resolvins are potent anti-inflammatory mediators derived from ω-3 fatty acids. Results from our previous studies indicated that resolvin D1 (RvD1) blocks pro-inflammatory responses in salivary glands. Furthermore, RvD1 enhances salivary epithelial integrity, demonstrating its potential use for the restoration of saliv...

journal_title：Journal of dental research

authors： Leigh NJ,Nelson JW,Mellas RE,Aguirre A,Baker OJ

更新日期：2014-03-01 00:00:00

abstract：:Retinoic acid-inducible gene I (RIG-I) is a cytosolic pattern recognition receptor involved in the sensing of RNA viruses and the initiation of antiviral responses. Fusobacterium nucleatum, a Gram-negative anaerobic bacterium associated with periodontal disease, is capable of invading cells. We hypothesized that F. nu...

journal_title：Journal of dental research

authors： Lee P,Tan KS

更新日期：2014-02-01 00:00:00

abstract：:The major phosphoprotein in dentin is the aspartic acid and serine-rich protein called dentin phosphophoryn (DPP). DPP appears to be synthesized as a part of a larger compound protein, dentin sialophosphoprotein (DSPP). DSPP has never been isolated or detected in dentin extracts. It is now evident that DSPP is a chime...

journal_title：Journal of dental research

authors： Zhang Y,Song Y,Ravindran S,Gao Q,Huang CC,Ramachandran A,Kulkarni A,George A

更新日期：2014-02-01 00:00:00

abstract：:Autosomal dominant mutations in PTH1R segregate with primary failure of eruption (PFE), marked by clinical eruption failure of adult teeth without mechanical obstruction. While the diagnosis of PFE conveys a poor dental prognosis, there are no reports of PFE patients who carry PTH1R mutations and exhibit any other ske...

journal_title：Journal of dental research

authors： Frazier-Bowers SA,Hendricks HM,Wright JT,Lee J,Long K,Dibble CF,Bencharit S

更新日期：2014-02-01 00:00:00

abstract：:Dental composites develop residual stresses during polymerization due to shrinkage. These stresses may change with time because of relaxation and water sorption in the oral environment. This phenomenon is likely dependent on the composition of the materials, specifically their hydrophilic characteristics, and could re...

journal_title：Journal of dental research

authors： Park JW,Ferracane JL

更新日期：2014-02-01 00:00:00

abstract：:Cell therapies utilizing mesenchymal stem cells (MSCs) could overcome limitations of traditional treatments for reconstructing craniofacial tissues. This large-scale study explored a standardized methodology for the isolation and clinical-scale expansion of alveolar bone marrow-derived MSCs (aBMSCs). We harvested 103 ...

journal_title：Journal of dental research

authors： Mason S,Tarle SA,Osibin W,Kinfu Y,Kaigler D

更新日期：2014-01-01 00:00:00

abstract：:The oral microbiome consists of a planktonic microbiome residing in saliva and an adhering microbiome (the biofilm adhering to oral hard and soft tissues). Here we hypothesized that possible differences in microbial composition of the planktonic and adhering oral microbiome on teeth can be related to the forces by whi...

journal_title：Journal of dental research

authors： Wessel SW,Chen Y,Maitra A,van den Heuvel ER,Slomp AM,Busscher HJ,van der Mei HC

更新日期：2014-01-01 00:00:00

abstract：:Inferior alveolar nerve (IAN) injury induces persistent ectopic pain which spreads to a wide area in the orofacial region. Its exact mechanism remains unclear. We investigated the involvement of nitric oxide (NO) in relation to ectopic orofacial pain caused by IAN transection (IANX). We assessed the changes in mechani...

journal_title：Journal of dental research

authors： Sugiyama T,Shinoda M,Watase T,Honda K,Ito R,Kaji K,Urata K,Lee J,Ohara K,Takahashi O,Echizenya S,Iwata K

更新日期：2013-12-01 00:00:00

abstract：:Dimensional alterations of the facial bone wall following tooth extractions in the esthetic zone have a profound effect on treatment outcomes. This prospective study in 39 patients is the first to investigate three-dimensional (3D) alterations of facial bone in the esthetic zone during the initial 8 wks following flap...

journal_title：Journal of dental research

authors： Chappuis V,Engel O,Reyes M,Shahim K,Nolte LP,Buser D

更新日期：2013-12-01 00:00:00

abstract：:The cariostatic benefit from water fluoridation is indisputable, but the knowledge of possible adverse effects on bone and fracture risk due to fluoride exposure is ambiguous. The association between long-term (chronic) drinking water fluoride exposure and hip fracture (ICD-7-9: '820' and ICD-10: 'S72.0-S72.2') was as...

journal_title：Journal of dental research

authors： Näsman P,Ekstrand J,Granath F,Ekbom A,Fored CM

更新日期：2013-11-01 00:00:00

abstract：:Due, in part, to the unique structure of the tooth, dental pain is initiated via distinct mechanisms. Here we review recent advances in our understanding of inflammatory tooth pain and discuss 3 hypotheses proposed to explain dentinal hypersensitivity: The first hypothesis, supported by functional expression of temper...

journal_title：Journal of dental research

authors： Chung G,Jung SJ,Oh SB

更新日期：2013-11-01 00:00:00

abstract：:This case-control study evaluated the association of headache and other co-morbid pain with temporomandibular disorder (TMD) pain in adolescents and explored the temporal co-variance of headache and TMD pain. In a population-based sample of 12- to 19-year-olds, 350 patients with self-reported TMD pain and 350 healthy ...

journal_title：Journal of dental research

authors： Nilsson IM,List T,Drangsholt M

更新日期：2013-09-01 00:00:00

abstract：:Phosphatases are involved in bone and tooth mineralization, but their mechanisms of action are not completely understood. Tissue-nonspecific alkaline phosphatase (TNAP, ALPL) regulates inhibitory extracellular pyrophosphate through its pyrophosphatase activity to control mineral propagation in the matrix; mice without...

journal_title：Journal of dental research

authors： McKee MD,Yadav MC,Foster BL,Somerman MJ,Farquharson C,Millán JL

更新日期：2013-08-01 00:00:00

abstract：:The frequency and impact of temporomandibular joint (TMJ) disorders necessitate research in characterizing the joint's function. The 6 discal attachments have not yet been systematically characterized under tension. Understanding their role in joint function may guide our study of TMJ pathologies, including disc displ...

journal_title：Journal of dental research

authors： Murphy MK,Arzi B,Hu JC,Athanasiou KA

更新日期：2013-08-01 00:00:00

abstract：:Vitamin D, an anti-inflammatory mediator, has potential benefits for physical and oral health. Although it is produced endogenously, some individuals have a greater need for dietary and supplemental sources. This repeated-measures cross-sectional study assessed associations between total vitamin D intake and periodont...

journal_title：Journal of dental research

authors： Alshouibi EN,Kaye EK,Cabral HJ,Leone CW,Garcia RI

更新日期：2013-08-01 00:00:00

abstract：:Caregivers' health literacy has emerged as an important determinant of young children's health care and outcomes. We examined the hypothesis that caregivers' health literacy influences children's oral-health-care-related expenditures. This was a prospective cohort study of 1,132 child/caregiver dyads (children's mean ...

journal_title：Journal of dental research

authors： Vann WF Jr,Divaris K,Gizlice Z,Baker AD,Lee JY

更新日期：2013-07-01 00:00:00

abstract：:The authors tested the hypothesis that obstructive sleep apnea (OSA) signs/symptoms are associated with the occurrence of temporomandibular disorder (TMD), using the OPPERA prospective cohort study of adults aged 18 to 44 years at enrollment (n = 2,604) and the OPPERA case-control study of chronic TMD (n = 1,716). In ...

journal_title：Journal of dental research

authors： Sanders AE,Essick GK,Fillingim R,Knott C,Ohrbach R,Greenspan JD,Diatchenko L,Maixner W,Dubner R,Bair E,Miller VE,Slade GD

更新日期：2013-07-01 00:00:00

abstract：:One of the main goals of bone tissue engineering is to identify and develop new biomaterials and scaffolds for structural support and controlled cell growth, which allow for formation or replacement of bone tissue. Recently, carbon nanotubes (CNT) have emerged as a potential candidate for bone tissue engineering. CNT ...

journal_title：Journal of dental research

authors： Martins-Júnior PA,Alcântara CE,Resende RR,Ferreira AJ

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study was to investigate the diffusion dynamics of 25% hydrogen peroxide (H2O2) through enamel-dentin layers and to correlate it with dentin's structural alterations. Micro-Raman Spectroscopy (MRS) and Fourier Transform Infrared Photoacoustic Spectroscopy (FTIR-PAS) were used to measure the spectra of ...

journal_title：Journal of dental research

authors： Ubaldini AL,Baesso ML,Medina Neto A,Sato F,Bento AC,Pascotto RC

更新日期：2013-07-01 00:00:00

abstract：:The Global Burden of Disease (GBD) 2010 Study produced comparable estimates of the burden of 291 diseases and injuries in 1990, 2005, and 2010. This article reports on the global burden of untreated caries, severe periodontitis, and severe tooth loss in 2010 and compares those figures with new estimates for 1990. We u...

journal_title：Journal of dental research

authors： Marcenes W,Kassebaum NJ,Bernabé E,Flaxman A,Naghavi M,Lopez A,Murray CJ

更新日期：2013-07-01 00:00:00

abstract：:This systematic review and meta-analysis assessed the efficacy of lasers in reducing dentin hypersensitivity (DH) as compared with placebo or no treatment. Seven electronic databases and a manual search resulted in 2,538 unique publications. After selection, 13 studies were included in the meta-analysis. A CONSORT-bas...

journal_title：Journal of dental research

authors： Sgolastra F,Petrucci A,Severino M,Gatto R,Monaco A

更新日期：2013-06-01 00:00:00

abstract：:Oral bacteria, including Streptococcus mutans and Streptococcus salivarius, contribute to tooth decay and plaque formation; therefore, it is essential to develop strategies to prevent dental caries and plaque formation. We recently showed that organo-selenium compounds covalently attached to different biomaterials inh...

journal_title：Journal of dental research

authors： Tran P,Hamood A,Mosley T,Gray T,Jarvis C,Webster D,Amaechi B,Enos T,Reid T

更新日期：2013-05-01 00:00:00